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Bare hos et mindretall er det funnet kjente sykdommer som kan medføre langvarig smerte, for eksempel artrose, revmatiske sykdommer eller nervelidelser.Det er fireplace «svake opioider» tilgjengelig i Norge: kodein, tramadol, dekstropropoksyfen og pentazocin. Disse er omtrent like effektive. Alle hearth har risiko for avhengighet og misbruk ved
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